There are a dozen agent frameworks and the list grows monthly. Instead of comparing feature matrices, use this decision tree.
For a simple ReAct agent with 3-5 tools, raw LLM API + a short Python loop might be simplest. A framework adds abstraction that may be more complexity than value for simple agents.
Start without a framework. Adopt one when you hit real pain that the framework solves.
Yes → Claude Agent SDK. Strong MCP integration, behavior parity with Claude Code, Anthropic-native.
Yes → LangGraph. Most provider-agnostic and has mature tooling.
Yes, role-based agents → CrewAI (simpler) or AutoGen (more flexible)
Yes, graph-based flow → LangGraph
Prototyping → CrewAI or a simple direct-API approach
Shipping to production → LangGraph, Claude Agent SDK, or your own framework on raw API
Already deep in LangChain → LangGraph (natural evolution)
Python data science team → AutoGen fits well
Greenfield → Claude Agent SDK or DIY
For 80% of production use cases: start with Claude Agent SDK if you're on Claude, or raw OpenAI/Anthropic API with your own small orchestrator. Add a framework only when you hit limits.
LangGraph is the most "production-ready" of the established frameworks for multi-model use.
CrewAI is the fastest way to prototype multi-agent ideas.
Build your agent logic behind your own interface so you can swap frameworks later. Frameworks change, models change, patterns change. The business logic you own. Abstract the framework.