Send too often and you're spam. Send too slowly and they forget. Good cadence is respectful enough to feel human and frequent enough to stay top of mind. The defaults below work in B2B.
For a 5-touch sequence over 22-25 days:
For high-volume sequences, spread sends across Tuesday/Wednesday/Thursday to avoid your entire campaign competing with itself in the inbox.
Sending from Pacific time to Eastern prospects at 8am PT = 11am ET. Late morning for the recipient, fine. Sending from Pacific at 8am ET = 5am PT. You're awake at 5am? It looks automated.
Good cold email tools (Instantly, Smartlead) support recipient-timezone sending. Use it. Every email hits at the recipient's 9am regardless of where you are.
Covered in detail on multi-inbox rotation. Limits:
The prospect should never get two emails from you in one day. The sequence automatically handles this, but if you run multiple campaigns, ensure global frequency caps so one prospect doesn't receive email 3 of Campaign A and email 1 of Campaign B on the same day.
For a 1,500 email/week operation:
Emails sent in these periods either get buried or land when your prospect returns to a backed-up inbox. Pause, resume when attention returns.
Default cadences (3-5 day gaps) work. But for your specific audience, test:
Enterprise buyers with long decision cycles often tolerate and respond better to slower cadences. SMB impulse buyers often respond better to faster.